Research Centre for Crystalline Materials

Research Centre for Crystalline Materials

Overview

The Research Centre for Crystalline Materials was established to be a focus for the understanding the how and why molecules assemble in the crystalline state as they do – with a particular passion for investigating polymorphism and related phenomena which is fundamental to the pharmaceutical industry. An emphasis is upon evaluating unusual modes of association relevant to drug/biomolecule interaction. Ultimately, we wish to control supramolecular assembly in the condensed phase for specific materials properties. The Centre also engages in the development of novel metal-based therapeutics and the repurposing of old drugs through co-crystal technology for the treatment of various disease: anti-cancer, anti-microbial, anti-viral, etc. Clearly, our endeavours relate to the United Nations Sustainable Development Goal No. 3: Good Health and Well-Being. Under the leadership of Distinguished Prof. Dr Edward R.T. Tiekink, our work has been described in well over 2,200 research publications and received over 30,000 citations (Google Scholar).

Our activities revolve around the systematic synthesis, physiochemical characterisation and computational chemistry evaluation of series of molecules. We are well-equipped with state-of-the-art instrumentation such as variable-temperature single crystal and powder X-ray diffraction; variable-temperature solution and solid-state NMR, IR and UV/Vis spectroscopy as well as CHN analysis. We welcome consultancy, “fee-for service” and, especially, collaborations. The RCCM particularly welcomes enquiries from potential graduate students.

Vision

To be a highly visible and productive National centre of excellence for crystallographic research in molecular materials, that is also internationally recognised as being at the forefront of research in chemical crystal engineering/development of new drugs.

Mission

  • To rationalise experimental molecular structure and determine the interplay between structure with the crystalline manifold
  • To determine, understand and predict the modes of association between molecules in crystals with the ultimate aim of designing crystals with desirable materials properties
  • To rationally develop novel pharmaceuticals with an emphasis on determining mechanisms of action

 

 

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